Science

Metabolic Engineering to Advance

the Standard of Care

Evan M. Levine

Chairman and CEO

Dr. J. Andrew Jones

Faculty Miami University and Inventor

Adams AM, Kaplan NA, Wei Z, Brinton JD, Monnier CS, Enacopol AL, Ramelot TA, and Jones JA.

“In vivo production of psilocybin in E. coli.” Metabolic Engineering 56 (2019): 111-119

Advantages Over Published Methods

PsyBio Bacterial

Synthesis

Chemical Synthesis

Yeast Synthesis

Natural Production

Space Requirements

GMP Family

GMP Family

GMP Family

Farming

Environmental

Considerations

Friendly

Toxic Catalyst, Solvenst, and Reagents

Friendly

Friendly

Product

Consistency

Pharmaceutical

Grade

Pharmaceutical Grade

Pharmaceutical Grade

10-Fold Batch-to-Batch Variation

Product

Stability

High Product Stability at Room Temperatureure

Multiple Unstable Reaction Intermediates

High Rate of Degradation during Fermentation

Prone to Degradation "Bluing Reaction"

Speed & simplicity of production

2-4 days 1 Pot Autocatalytic Process

5-15 Days Long Reaction Scheme

4-10 Days 1 pot autocatalytic Process

Weeks to Months Sensitive to Environmental conditions