Science
Metabolic Engineering to Advance
the Standard of Care
Evan M. Levine
Chairman and CEO
Dr. J. Andrew Jones
Faculty Miami University and Inventor
Adams AM, Kaplan NA, Wei Z, Brinton JD, Monnier CS, Enacopol AL, Ramelot TA, and Jones JA.
“In vivo production of psilocybin in E. coli.” Metabolic Engineering 56 (2019): 111-119
Advantages Over Published Methods
PsyBio Bacterial
Synthesis
Chemical Synthesis
Yeast Synthesis
Natural Production
Space Requirements
GMP Family
GMP Family
GMP Family
Farming
Environmental
Considerations
Friendly
Toxic Catalyst, Solvenst, and Reagents
Friendly
Friendly
Product
Consistency
Pharmaceutical
Grade
Pharmaceutical Grade
Pharmaceutical Grade
10-Fold Batch-to-Batch Variation
Product
Stability
High Product Stability at Room Temperatureure
Multiple Unstable Reaction Intermediates
High Rate of Degradation during Fermentation
Prone to Degradation "Bluing Reaction"
Speed & simplicity of production
2-4 days 1 Pot Autocatalytic Process
5-15 Days Long Reaction Scheme
4-10 Days 1 pot autocatalytic Process
Weeks to Months Sensitive to Environmental conditions